Injectable Synovial Fluid
for Intra-articular
Use in the treatment of Arthritis

What is in-Visco?

in-Visco is an intra-articular injection produced by biological fermantation method and including ‘hyaluronic acid’ that is in high-purity and is generally used in the treatment of Osteoarthritis. The product that is similar to joint-fluids found naturally in joints serves as lubricants and shock-absorber like joint-fluids. Namely, in-Visco is a biological material replacing with fluids which decrease or disappear in patients’ joints. It is Class-Three material which has CE and ISO certificates and which is suitable for European Standards.

Where to use?

•Treatment of Osteoarthritis
•Following artroscopy
•Following menuscal repairs
•Following anterior cruciate ligament reconstruction
•Following mozaicplasty
•Patients with isolated patella-femoral knee and as an adjuvant treatment or to delay operations in patients with osteokondral defects.

Features

•Source: Bacterial Fermentation
•Made of High Purity HA
•Bacterial Endotoxin < 0.001 IU/mg
•Protein Value < 0.0004%
•Molecular Weight is Between 1.6 - 2.4 MDa

How to use?

It is not different from other intraarticular injections types in terms of practice. It could be used either for a knee or for both these days

As a first step, the area which will be injected should be cleaned by an expert. Injection is checked whether the needle reaches the right area.

In case there is excess fluid in joints, this excess fluid is drawn and checked if it is inflammatory. When no dangerous situation is observed, the needle is leaved in the knee and in-Visco is injected into the area.

There is no risk to apply painkiller into joints during pre-period of the injection. Patients are advised to abstain from any activities which could make them tired for two or three days. According to its type and concentration, in-Visco gives treatment between 3-12 months.

Effects

in-Visco improves Sodium-Hyalunorate levels in joints in medium-term. It also helps mechanical functions of cartilage to repair by stimulating the body naturally. The product produces an effect as natural joint-fluid and it makes joint lubricitate as well as contributing the prevention of joint pain. Consequently, it relieves pain and relaxes patient.

It replaces synovial fluid after arthroscopy operations, increases mobility in the joint and helps prevent post-operative complications.

in-Visco Cross Linked

Some patients complain about temporary pain and pressure for 2-3 days after intra-articular injection is operated. This model in which the hyaluronic acid molecules are cross-linked to each other, prevents complaints as well as staying in the joint for longer periods and has a therapeutic effect. in-Visco is slippery and elastic. It concentrates in the required area according to the movement of the joint. In this way, patients not only get through the process more comfortably, but also get a longer treatment.

It has a structure that is fluid when the patient is immobile and hardens when the patient begins to move. It is liquid but hardens when movement begins and acts as a buffer in the joint. Thus, preventing wear and tear of the joints and preserving joint health.

Its molecular weight is between 5-6MDa. It has the values of a healthy joint fluid.

Figure SEM images of linear HA and cross-linked HA

Features

•Source: Bacterial Fermentation
•Made of Ultra Purity HA
•Bacterial Endotoxin < 0.001 IU/mg
•Protein Value < 0.0004%
•Molecular Weight is Between 5-6 MDa
•Cross Linking Agent: BDDE

 

Figure Shear thinnig behaviour of in-Visco

 

Rheological properties of in-Visco

 

Models: Cross Linked

2mL 1% (20mg) Intra-Articular Injection Cross-Linked Hyaluronic Acid
2mL 1.6% (32mg) Intra-Articular Injection Cross-Linked Hyaluronic Acid
2mL 2% (40mg) Intra-Articular Injection Cross-Linked Hyaluronic Acid
2mL 2.2% (44mg) Intra-Articular Injection Cross-Linked Hyaluronic Acid
2mL 2.4% (48mg) Intra-Articular Injection Cross-Linked Hyaluronic Acid
2mL 3% (60mg) Intra-Articular Injection Cross-Linked Hyaluronic Acid
3mL 2% (60mg) Intra-Articular Injection Cross-Linked Hyaluronic Acid
3mL 2.4% (72mg) Intra-Articular Injection Cross-Linked Hyaluronic Acid
3mL 3% (90mg) Intra-Articular Injection Cross-Linked Hyaluronic Acid

Models: Linear

2mL 1% (20mg) Intra-Articular Injection with Hyaluronic Acid
2mL 1.6% (32mg) Intra-Articular Injection with Hyaluronic Acid
2mL 2% (40mg) Intra-Articular Injection with Hyaluronic Acid
2mL 2.2% (44mg) Intra-Articular Injection with Hyaluronic Acid
2mL 2.4% (48mg) Intra-Articular Injection with Hyaluronic Acid
2mL 3% (60mg) Intra-Articular Injection with Hyaluronic Acid
3mL 2% (60mg) Intra-Articular Injection with Hyaluronic Acid
3mL 2.4% (72mg) Intra-Articular Injection with Hyaluronic Acid
3mL 3% (90mg) Intra-Articular Injection with Hyaluronic Acid

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